Said to help occasion direct spiritual experience, entheogens include such psychoactives as ayahausca, the peyote used by the Native American Church, and psilocybin mushrooms. What place might psychoactive sacramentals have in contemporary spiritual practices? Can the careful use of entheogens aid in spiritual development? What cautions ought to be considered? 25 new essays from leaders in religion, mental health, and allied fields address these questions.